Siècle(s) traité(s) : 17
Droits : Domaine public
Provenance : Archives territoriales de Guyane
Permalien : http://www.manioc.org/patrimon/GAD11008
GAD11008

Éditeur(s) : Paris : chez l'auteur Paris : imprimerie Quillau Paris : Mequignon
Siècle(s) traité(s) : 18
Droits : Domaine public
Permalien : http://www.manioc.org/patrimon/MMC16057-1
MMC16057-1

Extrait de : Sciences et voyages,n°103, p. 41-47, p. 51
Résumé : Article + photos 7 p. + 1 p.
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : ORkidé|Fonds privé Pierre Rostan
Permalien : http://www.manioc.org/patrimon/ORK12133
ORK12133

Éditeur(s) : Fort-de-France : Imprimerie du Gouvernement
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Communauté d'agglomération de La Rochelle. Médiathèque Michel-Crépeau
Permalien : http://www.manioc.org/patrimon/MMC16033
MMC16033

Extrait de : Sciences et voyages, n°51
Résumé : Article et photographies
Siècle(s) traité(s) : 20
Droits : Domaine public
Provenance : ORkidé|Fonds privé Pierre Rostan
Permalien : http://www.manioc.org/patrimon/ORK12132
ORK12132

Éditeur(s) : Paris : Challamel
Siècle(s) traité(s) : 18
Droits : Domaine public
Provenance : Collectivité territoriale de Martinique. Bibliothèque Schoelcher
Permalien : http://www.manioc.org/patrimon/SCH13096
SCH13096

Éditeur(s) : HAL CCSD BioMed Central
Résumé : International audience
BACKGROUND: Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract. In addition to estradiol (E2), a natural hormone, numerous compounds are able to bind ERs and modulate their activities. Among these compounds, phytoestrogens such as isoflavones, which are found in plants, are promising therapeutics for several pathologies. Glyceollins are second metabolites of isoflavones that are mainly produced in soybean in response to an elicitor. They have potentially therapeutic actions in breast cancer by reducing the proliferation of cancer cells. However, the molecular mechanisms driving these effects remain elusive. METHODS: First, to determine the proliferative or anti-proliferative effects of glyceollins, in vivo and in vitro approaches were used. The length of epithelial duct in mammary gland as well as uterotrophy after treatment by E2 and glyceollins and their effect on proliferation of different breast cell line were assessed. Secondly, the ability of glyceollin to activate ER was assessed by luciferase assay. Finally, to unravel molecular mechanisms involved by glyceollins, transcriptomic analysis was performed on MCF-7 breast cancer cells. RESULTS: In this study, we show that synthetic versions of glyceollin I and II exert anti-proliferative effects in vivo in mouse mammary glands and in vitro in different ER-positive and ER-negative breast cell lines. Using transcriptomic analysis, we produce for the first time an integrated view of gene regulation in response to glyceollins and reveal that these phytochemicals act through at least two major pathways. One pathway involving FOXM1 and ERα is directly linked to proliferation. The other involves the HIF family and reveals that stress is a potential factor in the anti-proliferative effects of glyceollins due to its role in increasing the expression of REDD1, an mTORC1 inhibitor. CONCLUSION: Overall, our study clearly shows that glyceollins exert anti-proliferative effects by reducing the expression of genes encoding cell cycle and mitosis-associated factors and biomarkers overexpressed in cancers and by increasing the expression of growth arrest-related genes. These results reinforce the therapeutic potential of glyceollins for breast cancer.
ISSN: 1478-811X

hal-01560288
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01560288
DOI : 10.1186/s12964-017-0182-1
PUBMED : 28666461

Éditeur(s) : Rouen : Bonaventure Le Brun

Droits : Domaine public
Provenance : Communauté d'agglomération de La Rochelle. Médiathèque Michel-Crépeau
Permalien : http://www.manioc.org/patrimon/MMC16028
MMC16028

Éditeur(s) : Paris : Desenne, Petit, Le Normand

Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18181
ADG18181

Éditeur(s) : Cayenne : Imprimerie du gouvernement
Résumé : Année 1871
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Collectivité territoriale de Guyane. Bibliothèque Alexandre-Franconie
Permalien : http://www.manioc.org/patrimon/FRA11269
FRA11269

Éditeur(s) : Paris : Julien, Lanier, Cosnard
Extrait de : Voyages et travaux des missionnaires de la Compagnie de Jésus pour servir de complément aux Lettres édifiantes, publiés par des pères de la même compagnie
Description : Tome 1 de "Voyages et travaux des missionnaires de la Compagnie de Jésus pour servir de complément aux Lettres édifiantes, publiés par des pères de la même compagnie"
Siècle(s) traité(s) : 17
Droits : Domaine public
Provenance : Collectivité territoriale de Guyane. Bibliothèque Alexandre-Franconie
Permalien : http://www.manioc.org/patrimon/FRA11074
FRA11074

Éditeur(s) : Fort-de-France: Imprimerie du Gouvernement
Résumé : Pages volantes au début qui n'appartiennent pas au livre, table des matières manuscrite
Siècle(s) traité(s) : 19
Droits : Domaine public
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG17020
ADG17020

Éditeur(s) : Paris : Desenne, Petit, Le Normand

Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18128
ADG18128

Éditeur(s) : Amsterdam : Jean Evertsz Cloppenburch
Siècle(s) traité(s) : 17
Droits : Domaine public
Provenance : Communauté d'agglomération de La Rochelle. Médiathèque Michel-Crépeau
Permalien : http://www.manioc.org/patrimon/MMC16127-2
MMC16127-2

Éditeur(s) : Paris ; Julien, Lanier, Cosnard et Cie.
Extrait de : Voyages et travaux des missionnaires de la Compagnie de Jésus pour servir de complément aux Lettres édifiantes, publiés par des pères de la même compagnie
Siècle(s) traité(s) : 17
Droits : Domaine public
Provenance : Collectivité territoriale de Martinique. Bibliothèque Schoelcher
Permalien : http://www.manioc.org/patrimon/SCH13179
SCH13179

Éditeur(s) : HAL CCSD Wiley
Résumé : International audience
ISSN: 1198-743X

hal-01118417
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01118417
DOI : 10.1016/j.cmi.2014.11.027
PUBMED : 25630459

Éditeur(s) : Paris : Imprimerie nationale
Résumé : An VII
Siècle(s) traité(s) : 18
Droits : Domaine public
Provenance : Communauté d'agglomération de La Rochelle. Médiathèque Michel-Crépeau
Permalien : http://www.manioc.org/patrimon/MMC16051-4
MMC16051-4

Éditeur(s) : HAL CCSD Elsevier
Résumé : International audience
Estrogen receptors (ERs) α and β are distributed in most tissues of women and men. ERs are bound by estradiol (E2), a natural hormone, and mediate the pleiotropic and tissue-specific effects of E2, such as proliferation of breast epithelial cells or protection and differentiation of neuronal cells. Numerous environmental molecules, called endocrine disrupting compounds, also interact with ERs. Phytoestrogens belong to this large family and are considered potent therapeutic molecules that act through their selective estrogen receptor modulator (SERM) activity. Using breast cancer cell lines as a model of estrogen-dependent proliferation and a stably ER-expressing PC12 cell line as a model of neuronal differentiating cells, we studied the SERM activity of major dietary compounds, such as apigenin, liquiritigenin, daidzein, genistein, coumestrol, resveratrol and zearalenone. The ability of these compounds to induce ER-transactivation and breast cancer cell proliferation and enhance Nerve Growth Factor (NGF) -induced neuritogenesis was assessed. Surprisingly, although all compounds were able to activate the ER through an estrogen responsive element reporter gene, they showed differential activity toward proliferation or differentiation. Apigenin and resveratrol showed a partial or no proliferative effect on breast cancer cells but fully contributed to the neuritogenesis effect of NGF. However, daidzein and zearalenone showed full effects on cellular proliferation but did not induce cellular differentiation. In summary, our results suggest that the therapeutic potential of phytoestrogens can diverge depending on the molecule and the phenotype considered. Hence, apigenin and resveratrol might be used in the development of therapeutics for breast cancer and brain diseases.
ISSN: 0041-008X

hal-01558816
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01558816
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01558816/document
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01558816/file/Lecomte%20et%20al.%20-%20Assessment%20of%20the%20potential%20activity%20of%20major%20diet.pdf
DOI : 10.1016/j.taap.2017.04.005

Éditeur(s) : Paris : Prault, Les Frères Jombert & Cellot
Siècle(s) traité(s) : 18
Provenance : Archives départementales de Guadeloupe
Permalien : http://www.manioc.org/patrimon/ADG18167
ADG18167

Éditeur(s) : Paris : Perrin
Résumé : Deuxième édition
Siècle(s) traité(s) : 17
Droits : Domaine public
Provenance : Ville de Pointe-à-Pitre. Réseau des bibliothèques
Permalien : http://www.manioc.org/patrimon/PAP11104
PAP11104